Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity
Identifieur interne : 000868 ( Main/Exploration ); précédent : 000867; suivant : 000869Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity
Auteurs : Meysam Hashemi [France] ; Axel Hutt [France] ; Jamie Sleigh [Nouvelle-Zélande]Source :
- Frontiers in Systems Neuroscience [ 1662-5137 ] ; 2014-11-27.
English descriptors
Abstract
The role of extra-synaptic receptors in the regulation of excitation and inhibition in the brain has attracted increasing attention. Because activity in the extra-synaptic receptors plays a role in regulating the level of excitation and inhibition in the brain, they may be important in determining the level of consciousness. This paper reviews briefly the literature on extra-synaptic GABA and NMDA receptors and their affinity to anesthetic drugs. We propose a neural population model that illustrates how the effect of the anesthetic drug propofol on GABAergic extra- synaptic receptors results in changes in neural population activity and the electroencephalogram (EEG). Our results show that increased tonic inhibition in inhibitory cortical neurons cause a dramatic increase in the power of both δ and α bands. Conversely, the effects of increased tonic inhibition in cortical excitatory neurons and thalamic relay neurons have the opposite effect and decrease the power in these bands. The increased δ−activity is in accord with observed data for deepening propofol anesthesia; but is absolutely dependent on the inclusion of extrasynaptic (tonic) GABA action in the model.
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Le document en format XML
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Because activity in the extra-synaptic receptors plays a role in regulating the level of excitation and inhibition in the brain, they may be important in determining the level of consciousness. This paper reviews briefly the literature on extra-synaptic GABA and NMDA receptors and their affinity to anesthetic drugs. We propose a neural population model that illustrates how the effect of the anesthetic drug propofol on GABAergic extra- synaptic receptors results in changes in neural population activity and the electroencephalogram (EEG). Our results show that increased tonic inhibition in inhibitory cortical neurons cause a dramatic increase in the power of both δ and α bands. Conversely, the effects of increased tonic inhibition in cortical excitatory neurons and thalamic relay neurons have the opposite effect and decrease the power in these bands. The increased δ−activity is in accord with observed data for deepening propofol anesthesia; but is absolutely dependent on the inclusion of extrasynaptic (tonic) GABA action in the model.</div></front></TEI><affiliations><list><country><li>France</li><li>Nouvelle-Zélande</li></country><region><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Metz</li><li>Nancy</li></settlement><orgName><li>Université de Lorraine</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Hashemi, Meysam" sort="Hashemi, Meysam" uniqKey="Hashemi M" first="Meysam" last="Hashemi">Meysam Hashemi</name></region><name sortKey="Hutt, Axel" sort="Hutt, Axel" uniqKey="Hutt A" first="Axel" last="Hutt">Axel Hutt</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Sleigh, Jamie" sort="Sleigh, Jamie" uniqKey="Sleigh J" first="Jamie" last="Sleigh">Jamie Sleigh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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